MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
نویسندگان
چکیده
منابع مشابه
MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
UNLABELLED Mengovirus, a member of thePicornaviridaefamily, has a broad cell tropism and can cause encephalitis and myocarditis in multiple mammalian species. Attenuation has been achieved by shortening the polycytidine tract in the 5' noncoding region (NCR). A poly(C)-truncated strain of mengovirus, vMC24, resulted in significant tumor regression in immunocompetent BALB/c mice bearing syngenei...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2016
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02810-15